Article/ Study design Population Procedure Program duration and frequency Hypertrophy protocol Outcome Limitations
Hsu et al. 2019

RCT
29 females

68-73 yrs old
TKA 24 Weeks

Phase 1: 1-4wks

Phase 2: 5-8wks

Phase 3 9-⁠24wks
Program:

Weeks 1-4 (60% of 1RM, 12 reps/set x 3 sets)

5-8 weeks (70% of 1RM, 12 reps / sets x 3 sets, 3 days a week)

9-24 weeks (80% 1RM, 12 reps / sets x 3 sets, 3 days a week)
Resistance training group had greater lower extremity muscle strength (knee ext and flexors)

Improved functional mobility in 6MWT and 30sec CST
Small sample size.

Female Only.

No long term follow up post 12 months.
Husby et al. 2009

RCT
24 participants

48-64 yrs old
THA 4 Weeks

Beginning 1/52 post-op

5 sessions/week
Program:
Program completed in addition to conventional program
Warm up: 10min bike erg (roughly 50%VO2 max).
Strength Training Program: (5RM = 85% of 1RM),
(When patient attains 6 RM, load increased by 5kg),
(When patient attains 6 RM, load increased by 1kg).
Rest: 2mins rest between sets.
Supervised physio 3-5/7 for 4/52.
Abduction strength, peak force and work efficiency improved in strength training program

No differences in gait patterns were revealed post intervention.
Small sample size.

Insufficient time period for optimal muscle adaptations
Husby et al. 2010

RCT
24 participants

<70yrs old
THA 4 Weeks

Beginning 1/52 post-op

5 sessions/week
Program:
Completed on top of conventional program
Warm up: 10min bike erg (roughly 50%VO2 max)

Strength Training Program: (5RM = 85% of 1RM),
(When patient attains 6 RM, load increased by 5kg),
(When patient attains 6 RM, load increased by 1kg).

Rest: 2mins rest between sets

Supervised physio 3-5/7 for 4/52.
Work efficiency significantly improved in the STG by 29% (P 0.034) compared with the CRG in the test after 6 mos.

No significant increase in muscle strength

Rate of force development (RFD) improved by 74% 12mos. Post op compared to control.
Group allocation not concealed.

No baseline comparability.

Assessors, therapists and subjects not blinded.

Small sample size.

Short training period (Wks).
Husby et al. 2018

RCT
41 participants

45-73 yrs old
TKA 8 Weeks

Beginning day 8 post op
3 sessions/week

30min/session
Program:
Maximal strength training:
Warm up: 10 mins walking or cycling

Performed at 80-90% 1RM.
Load: 4 x 5reps (high velocity concentric).
When able to perform 6RM, load was increased by 5 kg for leg presses and by 0.5-1 kg for knee extensions.
Rest: 1-2min between sets
MST group muscle strength 37% increase in Leg press and 43% knee extension compared to pre op

no statistical difference in 6MWT
Amount and intensity of physical activity among patients was not recorded between 6-12 months.

Small sample size
Jakobsen et al. 2014

RCT
82 patients

56-73 yrs old
TKA 6 Weeks

Beginning 7 days post-op

2 sessions/week

Duration of session 45-50min
Program:
Warm up: 5 mins unilateral cycling (Borg intensity 7-10/20)
Progressed to bilateral cycling when able to flex knee to 95deg
Progressive strength training (15 mins):
2 sets x 2 sec isometric, 3sec concentric & eccentric
  • Week 1: 12RM
  • Weeks 2-5: 10RM
  • Weeks 6-7: 8RM
Rest: 60-180sec between sets
No statistically significant difference.

(mean difference between groups: −11.3 meters [95% CI −45.4, 22.7]; ANOVA P = 0.51) or adjusted baseline scores (−16.1 meters [95% CI −48.6, 16.4]; ANCOVA P = 0.33).
No 1RM assessed.

Training commenced seven days postoperatively.
Madara et al. 2019

RCT
20 participants

Mean age 66yrs
THA 16 Weeks

18 sessions of PT

3 session/week
Program:
Weeks 1-6:
prescribed home exercise program (HEP) → HEP progressed at each PT visit

Using pedometer - increase PA increments by 20% by-weekly
70% 8RM with 3 sets x 8 reps.

Load: 3 sets x 8 reps, once presenting with minimal fatigue, increase to 3 sets x 10 reps once presenting with minimal fatigue, re-assess 8RM and add resistance accordingly; start back at 3 sets x 8 reps with added resistance.
Weeks 7-12:

Load: same as weeks 1-6 (progressively increasing)
Weeks 13-16:

Individualised exercises tailored to patient goals including return to sport
Load: same as previous weeks (progressively increasing)
IG 6MWT distance 23.4% increase vs control: 9.4% (p=0.01) increase

HOOS Jr IG: (p=0.034) 103% increase
CG: 60% increase

Non-surgical side hip abduction strength (p=0.01) IG increased hip strength (0.04 kg/BW, 26% increase)
CG decreased (-0.02 kg/BW, 11% decrease).
Small sample size.

Individualised programs elicit individual results and therefore hard to generalise.

Low Specificity of exercise programs used.

Initial home exercise program relies on patient motivation, accurate reporting and program adherence.

Study enrollment not randomised.

Significant age gap between control and experimental group.
Madsen et al. 2013

RCT
80 participants

58-75 yrs old
TKA 6 Weeks

2 sessions/week
Program:
Warm up: 5 min exercise bike + 5-10 BW squats

Load:
Session 2: 1 set x 10-12 reps.
Session 3-4: 2 sets x 10-12 reps.
Session 5-7: 3 sets x 10-12 reps.
Session 8-10: 2 sets x 6-8 reps.
Session 11-12: 3 sets x 6-8 reps.
3-6 month follow up.
IG walked faster (p=0.01)
Increased LEP values- (p=0.04)

IG exceeded CG in five-times sit to stand @ 6 month follow up (p=0.045)
No description for rest periods.

No 1RM assessed.

No precise mean age of participants was documented.
Matheis and Stöggl 2018

RCT
39 participants

44-87yrs old
THA (minimally invasive anterolateral) 6 days Program:
Day 1 (20 mins): Instructions, mobilisation with crutches

Day 2: PROM/AROM of the hip & gait instructions

Day 3-5: PROM/AROM of hip & training therapy (30 mins)

Day 6: Post test
Weight shifting – 1 min
Step sequence. up/down x10 e/s.
Abduction 3 x 10 80% intensity.
standing extension 3 x10 80% intensity.
Cross walker 2min each.
Rest: 1 min rest for all strength exercises
Increased hip flexion ROM

Increased hip extension and abduction

Faster 6MWT
No 1RM assessed.

Small sample size.

Mobility program rather than hypertrophy.

No weight-based strength training - only body weight or isometric contractions.

Lack of exercise specificity.
Mikkelson et al. 2012

RCT
44 participants

Mean age: 67yrs
THA 12 Weeks

Follow up at 4 and 12 weeks
Program:
Consisted of Supine, Sitting, and Standing exercises.
Load: 10 reps x 2/daily

Progression 4/52 post op
No supine exercises
Medium resistance band
Step exercise(15-20cm height)
Knee bend with back against wall
One legged stance
Intensified program effective in terms of pain, adherence, and compliance

Persistent hip abductor strength deficiencies in both groups post study.

Recommend more intensive early rehab protocol.
Exercises not suitable for all Pt’s

Short follow up

Measurement errors and limited test battery.
Mikkelsen et al. 2017

RCT
34 patients (15 female / 19 male)

Mean age: 65 yrs old
THA 10 Weeks

Beginning 1/52 post-op

2 sessions/week

30-40min/session
program:
Warm up: 5-10 mins stationary bike

Exercises:
Load: 10-12RM week1 → increased progressively to 8RM, 3 sets per exercise

Rest: 1 min rest between sets
Progressive resistance training can be implemented shortly post op with substantial load progression and no overall exacerbation of postoperative pain. Small sample size.

No 1RM assessed.
Min Ji Suh et al. 2017

RCT
34 participants

77yrs or younger
TKA 2 Weeks

30min/session
Program:
ECC-CON group (n=16)
Concentric knee extension 30% 1RM 3x15.
Concentric Leg curl 40-60% 1RM @ 3 x 8-10.
Extension 60-80% 1RM 3-5reps.
Curl 60-80% 1RM 3-5reps - 3min rest.
Extension - 1RM
Curl - 1RM
ECC-CON group
only knee extension - eccentric contractions.
Significant improvement in post op knee ext strength, increased endurance, and gait speed of surgical knee. Small sample size.

Insufficient training program duration (2 wks)
Petterson et al. 2009

RCT
200 participants

50-85yrs old
TKA 6 Weeks

Beginning 3-4 Weeks post-op

2-3 sessions/week

NMES: 1 hour/day
Program:
Specifically target quadriceps femoris muscle group.

Load: 2 sets of 10 reps (weights were increased to maintain 10 rep max).

NMES (neuromuscular electrical stimulation) component to program:
10 electrically elicited contractions of quads muscle.
Hypertrophy group was significantly stronger P=0.007 at 12mos.

Mean NMVIC was 21%less in standard care.

Worse functional performance at 12/12 in standard care.
High dropout rate

No 1RM assessed.
Suetta et al. 2004

RCT
36 participants

60-86yrs old
THA 12 Weeks

Beginning day 7 post op

3 sessions/week
Program:
Warmup: 10-minute warm-up on a stationary bicycle.

Training intensity was progressively increased:

Weeks 1-6: 3-5 sets of 10 reps

Weeks 6-12: 3-5 sets of 8 reps
Increase in functional performance in RT (30%) and (37%) reduction in LOS.

RT increased muscle mass, muscle strength, and functional performance.
RT program augmented CSA 12% 12 weeks after surgery.
Limited number of patients
(results cannot be generalized to a wider population)

No 1RM assessed.
Winther et al. 2020
(pain and load progression)

Exploratory study
42 patients

35-⁠76yrs old
26 THA
16 TKA
10 Weeks

Beginning day 15 post op

3 sessions/week
Program:
Warmup: 10-min warm-up; walking or ergometer cycling.

Load:
  • 4 sets of 5 reps
  • 85-90% of 1RM
  • High velocity concentric phase
→ Load increased when patient could perform > 5RM

Rest: 1-2 min between sets
Significant progressive load increase in leg press and hip abduction until final intervention week (p<0.01) Explorative study: small sample size, low power

Program started two weeks after surgery.
Winther et al. 2020 (postural sway)

unpublished data from a prospective RCT
54 patients

Mean age: 63 yrs old
THA
(posterior approach)
12 Weeks

3 sessions/week

Follow up at 3, 6 and 12 months
Program:
Warm-up: cycling, step, and treadmill walking.

Load:
  • 4–5 reps × 4 sets
  • Load equal to 85%–95% of 1RM
Other workouts used were aquatic exercises, balance training, range-of-motion exercises, massage, and sling exercises.
IG patients 25%–50% stronger leg press and hip abduction than the CG patients 3 and 6 months postoperatively (p ≤ 0.002).

3-month follow up; Decreased postural sway in IG patients
Failed to measure preoperative gait data in order to make comparisons with postoperative data.

Reduced sample size due to high drop out rate

Explorative design.
Winther et al. 2020

RCT
26 patients

35-76 yrs old
THA 10 Weeks

3 session/week
Program:
Warmup: cycling

Load:
  • 5 reps, 4 sets
  • 85-90% of 1RM
  • emphasis on concentric part of movement
  • load increased following 6RM
Rest: 1-2 min rest intervals
Leg press + hip abduction strength stronger than control at 3 and 6 months post op.

No significant differences at 12 months post op.
Patients' level of exercise not recorded from 6-12 months post op.

Small sample size.